论文题目：Optical Fiber Quantum Biosensor based on Surface Plasmon Polaritons for the Label-Free Measurement of Protein

作者：彭昀

导师：赵勇

发表刊物：Sensors and Actuators B: Chemical

论文收录：SCI

论文摘要：An enhanced taper-based quantum biosensor based on surface plasmon polaritons (SPPs) with gold coating that operates below the standard quantum limit (SQL) is demonstrated. The sensing structure in this work is fabricated from two Multi-mode fibers (MMFs) and a section of Single-mode fiber (SMF). The gold coating with thickness of 50 nm is prepared by applying the plasma-sputtering apparatus. When the concentration of the bovine serum albumin (BSA) around the proposed quantum biosensor is changed, the number of transmitted photons also changes. Therefore, the BSA concentration can be measured according to the change of transmitted photons. Experiment results show that the obtained sensitivity of the enhanced taper-based quantum biosensor is calculated to be 0.0342 /(mg/mL) with the fast response time of 5 s. And, the detection limit (DL) of the proposed biosensor is 0.971 μg/mL, which is one order of magnitude higher than that of the traditional surface plasmon resonance (SPR) probe. The twelve orders of magnitude reduction in intensity afforded by our biosensor should allow a commensurate reduce for equivalent photodamage. The detected estimation errors obtained from the experiment are beyond the SQL and they are very consistent with the quantum theory. Our work in this paper verified that the proposed quantum biosensor can realize the label-free measurement of protein molecules, which provides a new idea for biological engineering, disease detection and single molecule label-free detection.